�A study by researchers at the Joslin Diabetes Center has shown that a protein known for its role in inducement bone growth can also help push the developing of brownness fat, a "good" fat that helps in the expenditure of energy and plays a role in fighting obesity.
"Obesity is occurring at epidemic rates in the U.S. and universal and that impacts the risk and prognosis of many diseases," said Yu-Hua Tseng, Ph.D. an Assistant Investigator in the Joslin Section on Obesity and Hormone Action and lead author of the paper published in Nature. "We hope this study bathroom be translated into applications to facilitate treat or prevent obesity."
Tseng noted that obesity is a major risk cistron for type 2 diabetes and is closely joined to the metabolic syndrome, a collection of medical problems associated with insulin resistance that can lead to an increased risk of coronary artery disease, the buildup of memorial tablet in coronary thrombosis arteries that leads to heart attack and stroke.
In laboratory studies of mouse cells, Tseng and her colleagues identified that a bone-inducing protein called BMP-7 drives precursor cells that give rise to get on brown fat cells. According to Tseng, there ar two main types of fat cells in the body - white and brown.
"White fat cells ar the 'conventional' form of fat intentional to store energy. By contrast, the main role of brown University fat is to burn down calories by generating heat. Brown juicy cells largely disappear by adulthood in humans, just their precursors still remain in the body," Tseng explained.
A 2005 Joslin study by Dr. Tseng and colleagues observed genes that control the creation of the precursor cells of brown fat. Another more than recent 2007 Joslin study led by C. Ronald Kahn, M.D., head of the Joslin Section on Obesity and Hormone Action and likewise a coauthor of the current Nature study, base clusters of brown fat cells spread between bundles of muscleman fibers in an obesity-resistant strain of mice.
Now, this latest subject identified BMP-7 as the protein capable of inducing the formation and role of brown fat cells. According to the paper, delivery of BMP-7 into mice using adenovirus as a vector resulted in an increase in the development of brown fat tissue. In one of the experiments, the mice that developed brown fat tissue gained less weight than those that did not. In another experimentation, mice that received injections of progenitor cells - similar to stem cells - that had been pre-treated with BMP-7 also developed extra brown fat tissue.
The study sought to address a fundamental motion in adipocyte biology, to wit what controls the development of fat depots. BMPs are a family of proteins known to regulate organ formation during embryonic development. In this study, Dr. Tseng and her colleagues proposed that different members of BMPs settle brown versus white fat cell fate. Scientists hope that improved knowledge of fat development will lead to new drugs or therapeutic approaches to fight obesity.
"Diet and exercise ar still the best approaches for weight reduction in the general population," Tseng said. "However, for people who ar genetically predisposed to corpulency, these approaches may have very little effect."
"As we learn more about the controls of brown rich development, medical interventions to increase vim expenditure by brown fat inducing agents, such as BMP-7, may provide hope to these individuals in losing weight and preventing the metabolic disorders associated with corpulency," she said.
The study was funded by grants from the National Institutes of Health, the Tanita Healthy Weight Community and the Miles Shore 50th Anniversary Scholar Program of Harvard Medical School.
Others participating in the research were Tim J. Schultz, Tian Lian Huang, Jonathon N. Winnay, Cullen M. Taniguchi, Thien T. Tran, Ryo Suzuki, Daniel O. Espinosa, Yuji Yakamoto and C. Ronald Kahn, the Mary K. Iacocca Professor of Medicine at Harvard Medical School, all of the Joslin Section on Obesity and Hormone Action; Efi Kokkotou of Beth Israel Deaconess Medical Center; Molly J. Ahrens and Andrew T. Dudley of Northwestern University; Andrew W. Norris of University of Iowa Children's Hospital; and Rohit N. Kulkarni of the Joslin Section on Cellular and Molecular Physiology.
About Joslin Diabetes Center
Joslin Diabetes Center is the world's preeminent diabetes clinic, diabetes research heart and supplier of diabetes education. Joslin is consecrated to ensuring people with diabetes live long, good for you lives and offers real hope and progress toward diabetes prevention and a cure for the disease. Founded in 1898 by Elliott P. Joslin, M.D., Joslin is an autonomous nonprofit psychiatric hospital affiliated with Harvard Medical School. For more information about Joslin, call 1-800-JOSLIN-1 or visit http://www.joslin.org/.
Source: Kira Jastive
Joslin Diabetes Center
More info
Sunday 24 August 2008
Wednesday 6 August 2008
J.J. Johnson
Artist: J.J. Johnson
Genre(s):
Jazz
Discography:
Concepts in Blue
Year: 1996
Tracks: 7
Proof Positive
Year: 1994
Tracks: 7
Vivian
Year: 1992
Tracks: 10
Sonny Stitt; Bud Powell; J.J. Johnson
Year: 1990
Tracks: 17
Sonny Stitt
Year: 1990
Tracks: 17
Friday 27 June 2008
Dmx - Dmx To Lose A House Over Dog Clothing Deal
Rapper DMX is set to lose a New York building he owns because of a longrunning battle with a dog clothing company.
The star was ordered to pay Amusing Diversions $281,000 (GBP140,500) after the company filed suit in 2004, alleging DMX - real name Earl Simmons - reneged on an agreement to promote its canine wear range.
The firm has spent the past four years attempting to get DMX to pay up, and authorities are finally stepping in and forcing the sale of a $1 million (GBP500,000) townhouse in Harlem.
The sale is slated for 13 August (08), reports the New York Post.
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Thursday 19 June 2008
Ministry Of Sound - Striptease Schoolgirl Advert Broadcast Rapped
An advert showing a woman dressed as a schoolgirl conducting a striptease for two men should not have been shown when children were watching.
The UK's advertising watchdog criticised broadcaster Box Television after it showed an advert for a mobile download of a controversial music video on its The Hits channel.
In the advert, which had no time restrictions, clips of HTwoO and Platnum's video for their What's It Gonna Be single were shown.
The video provoked controversy after showing a group of men and women wearing school uniforms dancing in front of a school.
In another section a woman performs a striptease in a classroom for one of the men, revealing a lacy red bra and pants under the uniform.
Two viewers who saw the advert on Sunday morning and Thursday afternoon complained to the Advertising Standards Authority (ASA) that it was inappropriate to broadcast the clip when children could have been watching.
Producer Ministry of Sound Recordings said it had no plans to show the advert again while Box Television insisted it had not intended to cause offence.
The broadcaster added the music video itself had already been cleared by Ofcom over its "sexually provocative content".
In its adjudication the ASA warned The Hits of failing to apply scheduling restrictions to adverts inappropriate for children.
Earlier this year the watchdog criticised long-time foe Ryanair for depicting a young woman dressed as a schoolgirl with the strap-line "hottest back to school fares".
18/06/2008 00:01:00
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Thursday 5 June 2008
The King is dead, long live the King
TWILIGHT OF THE GODS: Well, I�m glad to read that CNN is at least contemplating the possibility of a day without Larry King on their network. You know it�s summer when most of the news you get arrives in the form of rumour � in this case, speculation that the news network will be offering King�s chair and red suspenders to Jay Leno when the time finally comes for the 74-year-old host of Larry King Live to retire.
Leno, as we know, is leaving The Tonight Show next year, his bosses at NBC having decided to transplant Conan O�Brien from the east to west coast and into an earlier time slot in the search for younger demographics. Leno isn�t exactly happy about it, and he�s been quietly � but not too quietly, as this is Hollywood � shopping around for a new gig with the potential to make his soon-to-be-former bosses realize their mistake.
According to Bill Zwecker of the Chicago Sun-Times, ABC and Fox have been talking to Leno, but it�s CNN who want to offer him �a late-night chatfest that could morph into Leno replacing Larry King.� It�s all in the realm of fantasy right now, apparently, and Leno could find himself growing old in his holding pattern CNN show waiting to replace King -- who was, after all -- the first journalist to interview Marconi after his landmark first wireless broadcast between England and Newfoundland�s Signal Hill in 1901, a seminal moment in the young journalist�s career, albeit one that was captured for posterity on a zoetrope, as Marconi was just inventing broadcasting at the time.
I�ve never made a secret of my mystification at King�s longevity at hosting soft-soap, often befuddled interviews with guests who are either friends and therefore very forgiving, or just openly bemused at the kindly but clueless old man on the other side of the table. The best King shows are inevitably the ones where some wary zookeeper brings a bunch of animals on the show, most of which � badgers, raccoons, even squirrels - King claims never to have heard of before. Leno, for all of his shortcomings, would be an improvement on an exponential scale.
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Tuesday 27 May 2008
The Tony Danza Tapdance Extravaganza
Artist: The Tony Danza Tapdance Extravaganza
Genre(s):
Metal
Metal: Alternative
Discography:
Demo
Year: 2006
Tracks: 3
The Tony Danza Tapdance Extravaganza (Re-Issue)
Year: 2005
Tracks: 11
The Tony Danza Tapdance Extravaganza
Year: 2004
Tracks: 7
Sunday 18 May 2008
Francesco Renga
Artist: Francesco Renga
Genre(s):
Pop
Discography:
Ferro e Cartone
Year: 2007
Tracks: 11
Earlier embarking on his solo career, singer/songwriter Francesco Renga spent 13 days with the band Timoria, whose get-go personification had formed when the members were noneffervescent in high school. After releasing seven-spot albums with them, Renga decided he cherished to strickle come out alone, releasing his solo debut -- self-titled and on Universal, the mark that alike housed Timoria -- in 2001, that sami course of study entry ane of its songs, "Raccontami," into the San Remo Festival, where he won the critics' newcomer awarding (alongside Roberto Angelini), thanks in contribution to his breathing in live performance. The next class Tracce came come out of the closet, followed by Camere con Viste in 2004. In 2005 Renga in one case once again appeared at San Remo, this clip to tied to a greater extent prosperous results: his vocal music, "Angelo," took offset printing blank space at the stallion festival, prompt a re-release of Camere bunco game Viste with the motivator inclusion of the fetching make up. In June 2007, Renga issued a single, "Cambio Direzione," in expectancy of the upcoming full-length, Ferro e Cartone, set to appear in October of the sami year.
Filter's Richard Patrick Says Sobriety Gave Him A Better, More Political Voice
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